Atviri finansavimo kvietimai

Terminas: 2027-02-16DigitalAgenda

Sustainability and resilience of climate projections and related data records for European and global science and policy

Expected Outcome:The action should contribute to all of the following expected outcomes:The EU climate data and infrastructure sovereignty is strengthened, securing access to essential observation and modelling data for European research community.Effective delivery of climate information relevant for European and global climate policy, including timely contributions to the IPCC assessments and UNFCCC processes.The resilience of the Earth System Grid Federation (ESGF) is strengthened in Europe and globally, and the foundations for an integrated, sustainable long-term operational solution are laid.Scope:The evolution of the geopolitical situation, with the associated changes in science funding priorities and data access policies represent a major threat to evidence-based decision making. The continuity of production, maintenance and open access to climate data, including observations and projections, is fundamental for European and global climate science and policy action. Steps to ensure sustainability and resilience of the strategic resources and infrastructures in Europe needed to deliver these data are imperative. Acting on this offers an opportunity for the EU to consolidate its leadership in climate science and foster critical climate data sovereignty.The action should address all the following aspects:Track the availability of climate change projections and related data records, as well as the evolution of the global compensation efforts, gaps and risks in the context o

Bringing innovative climate preparedness and resilience solutions closer to the market

Expected Outcome:In direct support of the upcoming European Integrated Framework for Climate Resilience, the successful project is expected to address all of the following outcomes:Climate preparedness and resilience innovative solutions, including Nature-Based solutions, advance in their investment journey and get closer to the market, strengthening the competitiveness of the companies and organisations developing them.Public authorities are mobilised to stimulate demand for climate adaptation solutions, thereby contributing to the development and maturity of the European resilience market.Structural and operational bottlenecks to the deployment of climate resilience solutions are identified, along with good practices, and policy-relevant insights are derived from lessons learned.Scope:RationalePreparedness to current and future climate change is increasingly recognised as a driver of innovation and an emerging economic opportunity. The growing impacts of climate change are accelerating demand for technologies, services, practices and solutions that enable societies and economies to anticipate and manage climate risks. Already in 2021, the EU Adaptation Strategy highlighted the importance of scaling such solutions in order to strengthen resilience across economic sectors and regions. Moreover, the 2025 Preparedness Union Strategy outlines the link between climate security and the need for stronger public-private cooperation as a critical pillar of the EU’s preparedness.As cl

Detection, monitoring, modelling, and attribution capabilities for Solar Radiation Modification (SRM) activities and assessing their impacts on Earth's climate and ecosystems

Expected Outcome:Projects are to contribute to all of the following outcomes:European Union’s, Member States’ and Associated Countries’ policy making is supported with robust evidence and their visibility in deliberations of SRM strengthened. Evidence and new knowledge related to the points below supports the European Union’s, Member States and Associated Countries’ contributions to relevant international review and assessment processes of SRM, notably by the IPCC:Civil society, researchers, public authorities as well as policy and decision makers have access to a solid scientific-technological knowledge foundation concerning the detection, attribution and deterrence of SRM activities as a contribution to an emerging multilateral governance system spanning both SRM-related research and technological development.The development of a global SRM governance framework is supported through advanced knowledge, generated by desk research, modelling, earth observation, the documentation of development pathways of various SRM technologies and their potential impacts on the earth system and its parts (oceans, large-scale atmospheric circulation, regional climate such as monsoons as well as changes in precipitation), as well as on societies (impact on decarbonisation pathways, livelihood security, nature dependent value chains etc.) and ecosystems. These are considered substantial gaps by the Intergovernmental Panel on Climate Change (IPCC), Convention on Biological Diversity (CBD) and G

Terminas: 2027-02-16EoscAndFairData

A stronger Global Ocean Observing System to enhance Europe’s strategic autonomy, climate resilience and biodiversity conservation

Expected Outcome:Proposals are expected to contribute to all the following expected outcomes, in full alignment with the OceanEye initiative:scientists, public authorities and businesses benefit from strengthened and resilient global ocean observing capacities, coordinated under the Intergovernmental Oceanographic Commission’s Global Ocean Observing System (GOOS),[1] through the deployment of ocean observation equipment, in particular for the provision of critical observations for marine biodiversity and ecosystem knowledge;public authorities prioritise investments on infrastructures and capacity building to advance ocean research, protect and restore ocean health and biodiversity and provide critical services through a global ocean observing system and data delivery that is fit-for purpose, cost efficient and designed across all its components;increased EU leadership and strategic autonomy in global ocean observation capabilities, in support of EU climate and biodiversity goals, strengthening the EU’s contribution to and influence within GOOS, and reducing the risk of critical dependencies, notably for key services (i.e. Copernicus Services);enhanced collaboration between observation communities, marine research infrastructures, European SMEs and technology providers, maritime industries, and service operators, actionably contributing to the validation, procurement readiness, uptake and large-scale deployment of innovative ocean observing technologies and approaches, in part

EU AI Media Platform – modular multilingual public-interest infrastructure for European news and audiovisual media (IA) - Apply AI

Expected Outcome:The project will support the development of a modular, trustworthy and interoperable AI-enabled infrastructure enabling pan-European public-interest media platform(s) to make available real time news and information from professional media outlets across the EU and associated countries to wider audiences[1]. It will harness AI to translate, process and distribute content for relevant channels through classification, recognition, linguistic analysis, translation and other multimodal workflows. It will also enable prototypic content creation and testing of immersive and innovation-inspired media experiences consistent with a public-interest mission for different age groups, taking into account gender-responsive design and promoting news diversity. Overall, it will improve multilingual access, including low-resource European languages, strengthen media pluralism and resilience for public service media and professional media outlets, content creators and independent publishers, and embed trust, provenance and accountability by design.The concrete expected outcomes are:Reliable, modular and interoperable infrastructure with validated service levels and sustainability pathways, integrating AI-based components that support multilingual and multimodal media workflows including audiovisual processing and adaptation workflows, relevant metadata interoperability for broadcast and streaming contexts, social-media-facing interaction and adaptive, personalised, and interac

Autonomous Drive Ambition Cities (IA) - Apply AI

Expected Outcome:Development and demonstration of AI-enabled electric autonomous mobility services (level 4) in urban traffic, improving safety, sustainability, data sharing and commercial scalability across cities, through a large-scale demonstrator integrating 5 - 7 co-ordinated city pilots in 5 or more Member States or associated countries including at least one cross-border pilot between adjacent cities - to bring near-to-market autonomous driving technologies into real operations: Delivery on the Apply AI Strategy flagship action “Autonomous Drive Ambition Cities” by bridging the gap between high technical maturity and sustainable commercial deployment in cities.Strengthened competitiveness of European base vehicle manufacturers, AD technology stack providers, mobility service brokers, and mobility service operators through real-world deployment opportunities as addressed by the European Connected and Autonomous Vehicle Alliance (ECAVA), in particular its working group on Autonomous Driving deployment.Safer, more sustainable and accessible urban mobility through the integration of electric autonomous vehicles.Demonstration of scalable autonomous mobility services and vehicles in real-traffic urban environments using mature autonomous driving technologies.Improved access to and secure sharing of data as well as AI models and tools to support the development, testing, validation and safe operation of autonomous driving systems.Demonstration of a scalable, future-proof supp

EU Frontier AI Initiative: Advanced Scaling Frameworks for High-Performance AI Models (RIA) - Apply AI

Expected Outcome:This topic aims to advance the scientific and technical foundations for the scaling of AI models, enhancing the performance of training and inference processes and providing European AI labs with the methodologies required to compete at the global frontier. Project results are expected to contribute to some of the following outcomes: Establishment of robust scaling laws and predictive frameworks that allow for the reliable estimation of model performance before large-scale compute investment.Enhanced competitiveness of European advanced AI models through optimised dataset mixtures, refined architectures, and superior hyperparameter configurations.Optimised development for frontier AI models, achieved via automated and scientifically grounded scaling methodologies.Scope:To maintain a leading position in AI, Europe must master the methodologies required to scale AI models’ performance, training and inference processes. Establishing a predictive methodology for AI model development ensures that limited computational resources are deployed with maximum efficiency, thereby bolstering the EU and AC’s technological sovereignty.While previous actions have focused on training High-Performance AI models, this topic addresses the research gap in the underlying theoretical basis, methodologies and tools for predictable scaling of AI models and inference. By providing the technical foundations for high-performance systems without the costs of unguided experimentation, thi

Large-Scale piloting of next-generation AI-driven digital platforms for a more affordable, secure and sustainable European energy system (IA) - Apply AI

Expected Outcome:Projects are expected to contribute to the following outcomes: Strengthened Europe’s technological leadership and sovereignty in the energy sector.Market-ready AI-driven digital platforms and solutions with quantifiable minimal environmental impact, that enhance grid operation, renewable energy integration and utilisation rates, energy storage integration, grid integration of data centres and other energy intensive critical infrastructures, non-fossil, balancing solutions, electrification and energy efficiency, derived from existing and ongoing AI and IoT research.Successfully integrate applied research results in real-world pilot programmes involving energy operators, technology providers, public authorities, and end users.Secure, interoperable, and cross-border data exchange mechanisms and digital services reducing fragmentation.Accelerated scaling of digital solutions leveraging European data spaces, AI factories[1], digital twins, and cloud-to-edge infrastructures.Credible pathway from innovation to large-scale piloting, ensuring long-term sustainability and scale up.Quantifiable improvements in terms of reduction in greenhouse gas emissions, energy savings, electricity cost reduction and grid flexibility. Scope:This topic will support one large-scale cross-border pilot project demonstrating the operational use of next-generation AI-driven Digital Platforms (DPs) for the European energy system, to optimize electricity system operation and flexibility mana

Terminas: 2027-02-16DigitalAgenda

Valorising Horizon project results via innovation ecosystems

Expected Outcome:Project results are expected to contribute to all of the following expected outcomes:owners of Horizon project results that are better prepared to bring their products, practices and solutions to the market, with clearer value propositions, validated user cases, and credible commercialisation pathways;strengthened links between research outcomes, Horizon Europe instruments and public/private knowledge intermediaries foster a more cohesive and responsive innovation journey;enhanced collaboration between research, education and innovation stakeholders (knowledge triangle) ensures more effective exploitation of impactful research results and stronger alignment with societal and industrial needs.Scope:A structural gap persists between research outcomes of Horizon 2020 Pillar III[1], Horizon Europe Pillar II (Horizon) and the initiatives supporting knowledge valorisation. While many Horizon projects end with experimental proof of concepts and laboratory validation, most market- and business-oriented support mechanisms (e.g. acceleration, investment or pre-commercial procurement) typically engage only at later stage, such as through validation in relevant environments, prototyping or demonstration. As a result, critical elements for innovation de-risking (e.g. identifying concrete use cases, validating results in real-world environments, defining customer segments, developing viable business models or intellectual property strategies) are often underdeveloped when

Ground and naval platforms and systems

Expected Impact:The results of the activities should contribute to support common procurement, leading to strengthening the cooperation among Member States and associated countries, as well as to greater interoperability. Furthermore, they should contribute to the development and the procurement of common platforms and subsystems.Objective:This topic aims to support the common procurement of a wide range of capabilities or systems of ground and naval platforms or parts thereof, including but not limited to artillery systems, (counter)-mobility platforms, tanks or other armoured vehicles, support vehicles, combat platforms, soldier systems, surface and underwater naval platforms or their sub-systems.Scope:Common procurement actions under this topic shall consist of activities related to the cooperation of legal entities in the procurement of ground, naval platforms and systems, at any point in the life cycle of such defence products, including for the purpose of establishing, managing and maintaining defence industrial readiness pools. To achieve the expected impact, the estimated value of a common procurement proposed for actions under this topic shall be at least EUR 80 000 000 aiming to commonly procure defence products to fill the capability gaps and reinforce cooperation among Member States and associated countries. The procurement shall be based on a binding agreement to be signed by the participating Member States and associated countries with a procurement agent appoin

Unmanned systems and counter-unmanned systems

Expected Impact:Projects are expected to deliver results aligned with the expected results set out in this call topic and to evidence their contribution through dedicated KPIs defined in the proposal. Expected results include: • demonstrable and sustainable increase in production capacity in UA for the targeted (counter-)UxS-related production lines; • measurable reduction of production lead time from order/production decision to delivery in UA; • improved timely availability and supply of defence products in UA, including increased delivery reliability and readiness of production lines; • effective cross-border cooperation between UA and EU that enables production ramp-up, integration, qualification and sustainment; • strengthened Ukrainian industrial base, and, where applicable, operationalised MaaS and dual-use heavy industry conversion pathways for surge. Proposals shall define, baseline and track KPIs such as: production output (units/month), time-to-rate, lead-time reduction, line availability/uptime, qualified output delivered in UA, MaaS throughput, surge conversion readiness indicators, and workforce trained where relevant—alongside risk-related indicators demonstrating supply robustness and maintainability readiness.Objective:This topic aims to reinforce (counter-)UxSs readiness and a sovereign UxSs component base by enabling the rapid industrial reinforcement of Member States and Ukraine for key defence product (including subcomponents) production lines: • (swarmin

C5ISR and other space-related products

Expected Impact:The results of the activities should contribute to support common procurement, leading to strengthening the cooperation among Member States and associated countries, as well as to greater interoperability. Furthermore, they should contribute to should contribute to the development and reinforcement of C5ISR and space-related products of the participants.Objective:The results of the activities should contribute to support common procurement, leading to strengthening the cooperation among Member States and associated countries, as well as to greater interoperability. Furthermore, they should contribute to the development and the procurement of common platforms and subsystems.Scope:Common procurement actions under this topic shall consist of activities related to the cooperation of legal entities in the procurement of C5ISR or other space-related defence products and systems, at any point in the life cycle of such defence products, including for the purpose of establishing, managing and maintaining defence industrial readiness pools. To achieve the expected impact, the estimated value of a common procurement proposed for actions under this topic shall be at least EUR 20 000 000 aiming to commonly procure defence products to fill the capability gaps and reinforce cooperation among Member States and associated countries. The procurement shall be based on a binding agreement to be signed by the participating Member States and associated countries with a procurement

Air and missile defence systems

Expected Impact:The results of the activities should contribute to support common procurement, leading to strengthening the cooperation among Member States and associated countries, as well as to greater interoperability. Furthermore, they should contribute to the development and reinforcement of air and missile defence capabilities of the participants.Objective:This topic aims at actions supporting the common procurement of integrated, multilayered, air and missile defence, or parts thereof including sensors (e.g. radars), kinetic or non-kinetic effectors, command and control, that protects against the full spectrum of air threats (cruise missiles, ballistic and hypersonic missiles, aircraft and UAS) from medium to long range, high and terminal high altitude, including endo-atmospheric interceptor. This topic does not cover very short to short range air defence systems against low altitude UAS (covered by call topic EDIP-P-2026-FNLC-CPA-CDS).Scope:Common procurement actions under this topic shall consist of activities related to the cooperation of legal entities in the procurement of air and missile defence systems, or parts thereof, at any point in the life cycle of such defence products, including for the purpose of establishing, managing and maintaining defence industrial readiness pools. To achieve the expected impact, the estimated value of a common procurement proposed for actions under this topic should be at least EUR 80 000 000 aiming to commonly procure defence pro

Platforms and end-products

Expected Impact:Projects are expected to deliver results aligned with the expected results set out in this call topic and to evidence their contribution through dedicated KPIs defined in the proposal. Expected results include: • tangible capacity increases in EU-based production enabling the ramp-up of the targeted platforms or end-products, with demonstrated contribution to competitiveness; • improved resilience & geographical distribution of supply and industrial capability, reducing single points of failure across forging/machining, key sub-systems, composites and assembly/integration; • strengthened availability and security of supply of the targeted platforms or end-products with identified risks and exposure to the risk of materialisation of conventional military threats; • and measurable lead-time reductions, establishment or availability of reserved capacity where applicable, and workforce trained to operate and sustain the reinforced production lines (including, where relevant, MaaS and dual-use conversion pathways). Proposals shall define, baseline and track KPIs such as added throughput (e.g., units/month of platforms/end-products or critical sub-systems; tonnes/month or batches for forging/machining/composites where relevant), time-to-rate, lead-time reduction, yield/quality improvements, qualified output delivered, reserved capacity parameters, numbers of staff trained, and indicators evidencing risk mitigation (e.g., supply-chain robustness, integration maturity

Key electronic components

Expected Impact:Projects are expected to deliver results aligned with the expected results set out in this call topic and to evidence their contribution through dedicated KPIs defined in the proposal. Expected results include: • tangible capacity increases in EU-based production of the targeted electronic components, with demonstrated contribution to competitiveness; • improved resilience & geographical distribution of supply, reducing single points of failure; • strengthened availability and security of supply for priority defence product production lines, commensurate with identified risks and exposure to the risk of • materialisation of conventional military threats; • and measurable lead-time reductions, establishment or availability of reserved capacity where applicable, and workforce trained to operate and sustain the reinforced production lines. Proposals shall define, baseline and track KPIs such as added throughput (units/month), time-to-rate, lead-time reduction, yield/quality improvements, qualified output delivered, reserved capacity parameters, and numbers of staff trained, alongside indicators evidencing risk mitigation (e.g., supply-chain robustness and obsolescence management outcomes). Where implemented, the physical and cyber protection WP is expected to deliver measurable improvements in site and production security, evidenced through threat assessment protected sites to support the security measures and KPIs (e.g., coverage of protected areas/assets, detec

Development of predictive biomarkers of disease progression and treatment response by using AI methodologies for chronic non-communicable diseases

Expected Outcome:This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination “Developing and using new tools, technologies and digital solutions for a healthy society”. To that end, proposals under this topic should aim to deliver results that are directed at, tailored towards and contributing to all the following expected outcomes:Clinical researchers and developers have access to novel predictive biomarkers to guide a more accurate assessment of disease progression and treatment response and tackle the unmet clinical needs of non-communicable chronic diseases.Clinicians and healthcare professionals use clinically validated predictive biomarkers for implementing more effective clinical research and personalised medicine with better health outcomes in chronic non-communicable diseases.Key stakeholders have access to trustworthy Artificial Intelligence (AI) tools to guide the development of multimodal predictive biomarkers of higher accuracy and clinical value when compared to the established practice.The citizens benefit of better health outcomes thanks to improved clinical guidelines and the implementation of effective biomarker-guided clinical research and personalised healthcare. Scope:Biomarkers[1] are invaluable tools for improving patient outcomes, guiding treatment decisions, accelerating personalised medicine, more effective clinical research and the development of better medicines.However, despite the s

Personalised approaches to reduce risks from Adverse Drug Reactions due to administration of multiple medications

Expected Outcome:This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination “Ensuring equal access to innovative, sustainable, and high-quality healthcare”. To that end, proposals under this topic should aim to deliver results that are directed at, tailored towards and contributing to all the following expected outcomes:Patients benefit from decreased incidence of Adverse Drug Reactions (ADRs) caused by the administration of multiple medications (three or more medicinal products[1]) and enhanced health outcomes by ensuring safer and more effective use of medication.Healthcare professionals can adopt adverse drug reactions prevention and reduction strategies to integrate genetic and other biomarker information into clinical decision-making to optimise the use of medication, especially in situations of comorbidities.Healthcare systems benefit from cost savings thanks to reduced hospital admissions and other costs associated with ADRs related to the intake of multiple medicines.Clinical and regulatory guidelines and policies for medication management in case of multiple medications can be revised supported by robust evidence.Educational programs for healthcare providers and patients benefit from improved awareness and management of polypharmacy and ADRs. Scope:While medicinal products contribute considerably to the health of EU citizens, they can also have adverse reactions. It is estimated that around 5% of all h

Development of monoclonal antibodies to prevent and treat infections from Flaviviruses

Expected Outcome:This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination “Tackling diseases and reducing disease burden”. To that end, proposals under this topic should aim to deliver results that are directed at, tailored towards and contributing to all the following expected outcomes:The scientific and clinical communities have a better understanding of and access to experimental monoclonal antibodies for the prevention and treatment of emerging or re-emerging viral infections, as well as for further clinical investigation.Candidate monoclonal antibody therapies are available to treat patients for emerging and re-emerging viral infections, increasing therapeutic options for clinical deployment in case of an epidemic or pandemic. Scope:Infectious diseases remain a major threat to health and health security in the EU and globally. Viral disease emergence is already being accelerated by climate change, and thus a proactive approach to the development of antiviral prophylactics and therapeutics in preparedness for future infectious disease outbreaks is needed. The capacity to produce antibodies that can target new variants and rapidly increase production would serve as an essential preparedness strategy against future health threats, whether from infectious disease epidemics or pandemics.This topic contributes to strengthening the Research and Innovation ecosystem within the EU and supports the implementation

Development of monoclonal antibodies to prevent and treat infections from Filo-, Nairo-, Phenui-, Picorna- and Toga viruses

Development of innovative antimicrobials against pathogens resistant to antimicrobials

Expected Outcome:This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination “Tackling diseases and reducing disease burden”. To that end, proposals under this topic should aim to deliver results that are directed at, tailored towards and contributing to all the following expected outcomes:The scientific and clinical communities have a better understanding of and access to new and innovative products for the treatment of antimicrobial resistant bacteria and fungi, as well as for further clinical investigation.Candidate therapies are available to treat patients for antimicrobial resistant bacteria and fungi, increasing therapeutic options for clinical deployment in the fight against Antimicrobial Resistance (AMR). Scope:The rapid rise of AMR presents a formidable threat to public health, challenging our ability to treat infections that were once easily managed with standard antimicrobials. As pathogens continually adapt and develop resistance to existing drugs, the efficacy of these treatments diminishes, leading to more severe and prolonged illnesses, increased healthcare costs and productivity losses, and higher mortality rates. This escalating crisis underscores an urgent need for viable therapeutic alternatives required to reduce the burden of diseases caused by antibiotic resistance. Innovative solutions are crucial to maintaining effective disease management and safeguarding public health.Proposals should p

Addressing disabilities through the life course to support independent living and inclusion

Expected Outcome:This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination “Staying healthy in a rapidly changing society”. To that end, proposals under this topic should aim to deliver results that are directed at, tailored towards and contributing to all the following expected outcomes:Persons with disabilities are empowered and can enjoy their rights to live independently, participate in society and be included in the community on an equal basis with others.The scientific community develops innovative solutions with a focus on removing barriers faced by persons with disabilities to live independently and they are provided with community support services where they live in the community.Policymakers, health and care services, social and service providers, disability organisations, funders, the scientific community, and other relevant bodies are informed of the research advances and best practices addressing the health and needs of persons with disabilities to support them living independently and being included in society. Scope:The focus of this topic is human-centred on persons with long-term disabilities[1] -physical, mental, intellectual or sensory- aiming at supporting independent living across the life-course from a health perspective. Persons with disabilities have an equal right to live independently and be included in the community. Independent living requires a differentiated landscape of quality,

Development of novel small molecule antiviral therapeutics for pathogens with epidemic potential

Expected Outcome:This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination “Tackling diseases and reducing disease burden”. To that end, proposals under this topic should aim to deliver results that are directed at, tailored towards and contributing to all the following expected outcomes:The scientific and clinical communities have a better understanding of and access to experimental antivirals for the prevention and treatment of emerging or re-emerging viral infections, as well as for further clinical investigation.Candidate antiviral therapies are available to treat patients for emerging and re-emerging viral infections, increasing therapeutic options for clinical deployment in case of an epidemic or pandemic. Scope:Infectious diseases remain a major threat to health and health security in the EU and globally. Viral disease emergence is already being accelerated by climate change, and thus a proactive approach to the development of antiviral prophylactics and therapeutics in preparedness for future infectious disease outbreaks is needed. The availability of antivirals targeting conserved viral or host mechanisms would provide a critical preparedness measure against future health threats caused by (re)emerging infectious disease epidemics or pandemics, due to infectious disease epidemics or pandemics.This topic contributes to strengthening the Research and Innovation ecosystem within the EU and supports the i

Development of cell-free protein synthesis platforms for discovery and/or production of biologicals

Expected Outcome:This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination “Maintaining an innovative, sustainable, and competitive EU health industry”. To that end, proposals under this topic should aim to deliver results that are directed at, tailored towards and contributing to all the following expected outcomes:Biopharmaceutical industries get access to streamlined development and production processes for peptide- or protein-based biologicals.Health systems benefit from the availability of enhanced or decentralised production systems for innovative health technologies that involve peptides or proteins, and which improve health and care.Citizens and patients will benefit from better access, availability and affordability of pharmaceuticals based on biologicals. Scope:Cell-Free Protein Synthesis (CFPS) has been employed in fundamental biological research for decades, however, interest for the approach as a viable means for drug development and production has only emerged in recent years. The advantages that CFPS provides in terms of efficiency, simplicity, flexibility, cost- and time savings outweigh the hurdles that are still to be overcome for CFPS to become a routine manufacturing system for peptide- or protein-based biologicals.Currently, there are several CFPS systems used that are either based on prokaryotic or eukaryotic cell lysates (including mammalian) or fully synthetic systems consisting of all